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Learn more by clicking on the individual cell types
Mesodermal angioblast
Multipotent cells that are involved in the continued generation of the mesoderm, and the development of blood vessels and epithelial cells.
Mesodermal angioblast markers
- CD34
- VEGF RECEPTOR 2
Endothelial cells
Forms the lining of vessels and sinusoids, and proliferates to retain this lining. Regulates interaction between blood, lymph and surrounding tissue.
Endothelial cells markers
- CD31
- CD45
- CD54
- CD106
Mesodermal progenitors
Derived from undifferentiated stromal mesenchymal cells in the bone marrow. Being heterogeneous, mesodermal progenitor cells are able to differentiate into various mesodermal cell lineages and also into endothelial cells. They are defined by having high aldehyde dehydrogenase activity and express embryonic markers.
Mesodermal progenitors markers
- CD105
- CD166
- CD15
Mesoderm
Middle germ layer, which forms the connective tissue and muscle.
Lymphatic endothelial cells
Morphologically and physiologically different to all other endothelial cells, the lymphatic subtype is derived from the venous endothelial cell by the expression of Sox18 and Prox1 transcription factors.
Lymphatic endothelial cells markers
- Prox1
- Podoplanin
- LYVE-1
- VEGF RECEPTOR 3
- CD31
- CD206
Venous endothelial cells and capillary cells
Morphologically and physiologically different to all other endothelial cells, the venous subtype is developed in part by the expression of Sox7, Sox17 and Sox18 genes, and the expression of EphB4.
Venous endothelial cells and capillary cells markers
- EphB4
- Neuropilin 1
- VEGF RECEPTOR 1
- VEGF RECEPTOR 2
- CD62
- CD31
- CD43
- CD105
- CD106
- CD54
Arterial endothelial cells
Morphologically and physiologically different to all other endothelial cells, the arterial subtype is formed by the action of a number of factors including EphrinB2, VEGF and Notch, under high shear stress.
Arterial endothelial cells markers
- EphB2
- Neuropilin 1
- Notch1
- Notch2
- Notch3
- Delta-Like 4
- VEGF RECEPTOR 1
- VEGF RECEPTOR 2
- CD339
- Jagged2
Endothelial cells
Endothelial cells form the lining of a blood vessel and serve as an anticoagulant barrier between the vessel wall and blood. These cells also play critical roles in controlling vascular function, and participate in vascular homeostasis, thrombosis, inflammation and vascular wall remodeling.
Endothelial cells markers
- CD13
- CD31
- CD34
- CD40
- CD62
- CD81
- CD141
- CD206
- CD324
- VEGF
- CD54
- CD102
- CD105
- CD106
- VEGF RECEPTOR 1
- VEGF RECEPTOR 2
- VEGF RECEPTOR 3
- LYVE-1
- Podoplanin
